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Selected Publications



1.      X. Liu, F. Zhang, X. Jing, M. Pan, P. Liu, W. Li, B. Zhu, J. Li, H. Chen, L. Wang, J. Lin, Y. Liu, D. Zhao, H. Yan, C. Fan, Complex silica composite nanomaterials templated with DNA origami. Nature 559, 593 (2018).

2.      Y. Gu, W. Wang, Y. Li, Q. Wu, S. Tang, J. Yan, M. Zheng, D. Wu, C. Fan, W. Hu, Z. Chen, Y. Fang, Q. Zhang, Q. Dong, B. Mao, Designable ultra-smooth ultra-thin solid-electrolyte interphases of three alkali metal anodes. Nature Commun. 9, 1339 (2018).

3.      Q. Liu, Z. Ge, X. Mao, G. Zhou, X. Zuo, J. Shen, J. Shi, J. Li, L. Wang, X. Chen, C. Fan, Valency-Controlled Framework Nucleic Acid Signal Amplifiers. Angew. Chem. Int. Ed. 57, 7131 (2018).

4.      P. Liu, Y. Zhao, X. Liu, J. Sun, D. Xu, Y. Li, Q. Li, L. Wang, S. Yang, C. Fan, J. Lin, Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes. Angew. Chem. Int. Ed. 57, 5418 (2018).

5.      G. Xu, Q. Yan, X. Lv, Y. Zhu, K. Xin, B. Shi, R. Wang, J. Chen, W. Gao, P. Shi, C. Fan, C. Zhao, H. Tian, Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission. Angew. Chem. Int. Ed. 57, 3626 (2018).

6.      Z. Wang, Y. Luo, X. Xie, X. Hu, H. Song, Y. Zhao, J. Shi, L. Wang, G. Glinsky, N. Chen, R. Lal, C. Fan, In-situ Spatial Complementation of Aptamer-mediated Recognition Enables Live-cell Imaging of Native RNA Transcripts in Real Time. Angew. Chem. Int. Ed. 57, 972 (2018).

7.      Y. Zhang, Z. Shuai, H. Zhou, Z. Luo, B. Liu, Y. Zhang, L. Zhang, S. Chen, J. Chao, L. Weng, Q. Fan, C. Fan, W. Huang, L. Wang, Single-Molecule Analysis of MicroRNA and Logic Operations Using a Smart Plasmonic Nanobiosensor. J. Am. Chem. Soc. 140, 3988 (2018).

8.      W. Lai, L. Ren, Q. Tang, X. Qu, J. Li, L. Wang, L. Li, C. Fan, H. Pei, Programming Chemical Reaction Networks Using Intramolecular Conformational Motions of DNA. ACS Nano 12, 7093 (2018).

9.      Z. Wang, W. Liu, J. Shi, N. Chen, C. Fan, Nanoscale delivery systems for cancer immunotherapy. Mater. Horizons 5, 344 (2018).

10.  D. Ye, X. Zuo, C. Fan, DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development. Ann. Rev. Anal. Chem. 11, 171 (2018).


1.   J. Li, A. A. Green, H. Yan, C. Fan, Engineering nucleic acid structures for programmable molecular circuitry and intracellular biocomputation. Nature Chem. 9, 1056 (2017).

2.  X. Zuo, C. Fan, H. Chen, CRISPR-powered diagnostics. Nature Biomed. Eng. 1, 0091 (2017).

3.   H. Zhang, J. Chao, D. Pan, H. Liu, Y. Qiang, K. Liu, C. Cui, J. Chen, Q. Huang, J. Hu, L. Wang, W. Huang, Y. Shi, C. Fan, DNA origami-based shape IDs for single-molecule nanomechanical genotyping. Nature Commun. 8, 14738 (2017).

4.   M. Liu, Q. Li, L. Liang, J. Li, K. Wang, J. Li, M. Lv, N. Chen, H. Song, J. Lee, J. Shi, L. Wang, R. Lal, C. Fan, Realtime visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging. Nature Commun. 8, 15646 (2017).

5.  W. Qin, T. Peng, Y. Gao, F. Wang, X. Hu, K. Wang, J. Shi, D. Li, J. Ren and C. Fan, Catalysis-driven Self-Thermophoresis of Janus Plasmonic Nano- motors. Angew. Chem. Int. Ed. 56, 515 (2017).

6.  J. Wang, J. Chao, H. Liu, S. Su, L. Wang, W. Huang, I. Willner, C. Fan, Clamped Hybridization Chain Reactions for the Self-Assembly of Patterned DNA Hydrogels. Angew. Chem. Int. Ed. 56, 2171 (2017).

7.   X. Qu, D. Zhu, G. Yao, S. Su, J. Chao, H. Liu, X. Zuo, L. Wang, J. Shi, L. Wang, W. Huang, H. Pei, C. Fan, An Exonuclease III-Powered on-particle Stochastic DNA Walker. Angew. Chem. Int. Ed. 56, 1855 (2017).

8.   X. Ouyang, M. D. Stefano, A. Krissanaprasit, L. B. Kodal, C. B. Rosen, T. Liu, S. Helmig, C. Fan, K. V. Gothelf, Docking of Antibodies into Cavities in DNA Origami. Angew. Chem. Int. Ed. 56, 14423 (2017).

9.    J. Shen, Q. Tang, L. Li, J. Li, X. Zuo, X. Qu, H. Pei, L. Wang, C. Fan, Valence-Engineering of Quantum Dots Using Programmable DNA Scaffolds. Angew. Chem. Int. Ed. 56, 16077 (2017).

10. J. Shen, B. Luan, H. Pei, Z. Yang, X. Zuo, G. Liu, J. Shi, L. Wang, R. Zhou, W. Chen, C. Fan, Humidity-responsive single-nanoparticle-layer plasmonic films. Adv. Mater. 29, 1606796 (2017).

11. X. Qu, S. Wang, Z. Ge, J. Wang, G. Yao, J. Li, X. Zuo, J. Shi, S. Song, L. Wang, L. Li, H. Pei, C. Fan, Programming cell adhesion for on-chip sequential Boolean logic functions. J. Am. Chem. Soc. 139, 10176 (2017).

12. Z. Wang, Y. Fu, Z. Kang, X. Liu, N. Chen, Q. Wang, Y. Tu, L. Wang, S. Song, D. Ling, H. Song, X. Kong, C. Fan, Organelle-Specific Triggered Release of Immunostimulatory Oligonucleotides from Intrinsically Coordinated DNA–Metal–Organic Frameworks with Soluble Exoskeleton. J. Am. Chem. Soc. 139, 15784 (2017).

13. L. Sun, Y. Gao, Y. Xu, J. Chao, H. Liu, L. Wang, D. Li, C. Fan, Real-Time Imaging of Single-Molecule Enzyme Cascade Using a DNA Origami Raft. J. Am. Chem. Soc. 139, 17525 (2017).

14. P. Song, D. Ye, X. Zuo, J. Li, J. Wang, H. Liu, M. T. Hwang, J. Chao, S. Su, L. Wang, J. Shi, L. Wang, W. Huang, R. Lal, C. Fan. DNA Hydrogel with Aptamer-Toehold-Based Recognition, Cloaking, and Decloaking of Circulating Tumor Cells for Live Cell Analysis. Nano Lett. 17, 5193 (2017).

15. F. Chen, M. Bai, K. Cao, Y. Zhao, X. Cao, J. Wei, N. Wu, J. Li, L. Wang, C. Fan, X. Zhao. Programming Enzyme-Initiated Autonomous DNAzyme Nanodevices in Living Cells. ACS Nano 11, 11908 (2017).

16. X. Wang, F. Chen, D. Zhang, Y. Zhao, J. Wei, L. Wang, S. Song, C. Fan, Y. Zhao. Single copy-sensitive electrochemical assay for circulating methylated DNA in clinical samples with ultrahigh specificity based on a sequential discrimination–amplification strategy. Chem. Sci. 8, 4764 (2017).

17.  Y. Zhu, J. Zhang, A. Li, Y. Zhang , C. Fan, Synchrotron-based X-ray microscopy for sub-100 nm resolution cell imaging. Curr. Opin. Chem. Biol. 39, 11 (2017).



1.   F. Wang and C. Fan, DNA reaction networks: providing a panoramic view. Nature Chem. 8, 738 (2016).

2.   M. Lin, P. Song, G. Zhou, X. Zuo, A. Aldalbahi, J. Shi and C. Fan, Electrochemical detection of nucleic acids, proteins, small molecules and cells using a DNA nanostructure-based universal biosensing platform. Nature Protocols 11, 1244 (2016).

3.  Y. Zhang, Z. Cui, H. Kong, K. Xia, L. Pan, J. Li, Y. Sun, J. Shi, L. Wang, Y. Zhu and C. Fan, One-shot immunomodulatory nanodiamond agents for cancer immunotherapy. Adv. Mater. 28, 2699 (2016).

4.  Y. Zhang, Z. Wang, X. Li, L. Wang, M. Yin, L. Wang, N. Chen, C. Fan and H. Song, Dietary Iron Oxide Nanoparticles Delay Aging and Ameliorate Neurodegeneration in Drosophila. Adv. Mater. 28, 1387 (2016).

5.   D. Zhu, H. Pei, G. Yao, L. Wang, S. Su, J. Chao, L. Wang, A. Aldalbahi, S. Song, J. Shi, J. Hu, C. Fan and X. Zuo, A surface-confined proton-driven DNA pump using a dynamic 3D DNA scaffold. Adv. Mater. 28, 6860 (2016).

6.   Y. Zhang, Q. Li, L. Guo, Q. Huang, J. Shi, Y. Yang, D. Liu and C. Fan, Ion-Mediated Polymerase Chain Reactions Performed with an Electronically Driven Microfluidic Device. Angew. Chem. Int. Ed. 55, 12450 (2016).

7.   Y. Zhang, J. Chao, H. Liu, F. Wang, S. Su, B. Liu, L. Zhang, J. Shi, L. Wang, W. Huang, L. Wang and C. Fan, Transfer of Two-Dimensional Oligonucleotide Patterns onto Stereocontrolled Plasmonic Nanostructures through DNA-Origami-Based Nanoimprinting Lithography. Angew. Chem. Int. Ed. 55, 8036 (2016).

8.   X. Mao, A. J. Simon, H. Pei, J. Shi, J. Li, Q. Huang, K. W. Plaxco and C. Fan, Activity modulation and allosteric control of a scaffolded DNAzyme using a dynamic DNA nanostructure. Chem. Sci. 7, 1200 (2016).

9.   S. Wang, X. Cai, L. Wang, J. Li, Q. Li, X. Zuo, J. Shi, Q. Huang and C. Fan, DNA orientation-specific adhesion and patterning of living mammalian cells on self-assembled DNA monolayers. Chem. Sci. 7, 2722 (2016).

10.   Z. Hu, M. Sun, M. Lv, L. Wang, J. Shi, T. Xiao, Y. Cao, J. Wang and C. Fan, Deciphering buried air phases on natural and bioinspired superhydrophobic surfaces using synchrotron radiation-based X-ray phase-contrast imaging. NPG Asia Mater.  8, e306 (2016).

11. S. Su, Y. Wu, D. Zhu, J. Chao, X. Liu, Y. Wan, Y. Su, X. Zuo, C. Fan, L. Wang, On-Electrode Synthesis of Shape-Controlled Hierarchical Flower-Like Gold Nanostructures for Efficient Interfacial DNA Assembly and Sensitive Electrochemical Sensing of MicroRNA. Small 12, 37994 (2016).



1.   H. Liu, J. Wang, S. Song, C. Fan and K. V. Gothelf, A DNA-based system for selecting and displaying the combined result of two input variable. Nature Commun. 6, 10089 (2015).

2.  Y. Zhao, F. Chen, Q. Li, L. Wang and C. Fan, Isothermal Amplification of Nucleic Acids. Chem. Rev. 115, 12491 (2015).

3.  M. Lin, J. Wang, G. Zhou, J. Wang, N. Wu, J. Lu, J. Gao, X. Chen, J. Shi, X. Zuo and C. Fan, Programmable engineering of biosensing interface with tetrahedral DNA nanostructures for ultrasensitive DNA detection. Angew. Chem. Int. Ed. 54, 2151 (2015).

4.  G. B. Yao, J. Li, J. Chao, H. Pei, H. J. Liu, Y. Zhao, J. Y. Shi, Q. Huang, L. H. Wang, W. Huang and C. H. Fan, Gold-Nanoparticle-Mediated Jigsaw-Puzzle-like Assembly of Supersized Plasmonic DNA Origami. Angew. Chem. Int. Ed. 54, 2966 (2015).

5.   J. Yan, C. Y. Hu, P. Wang, B. Zhao, X. Y. Ouyang, J. Zhou, R. Liu, D. N. He, C. H. Fan and S. P. Song, Growth and Origami Folding of DNA on Nanoparticles for High-Efficiency Molecular Transport in Cellular Imaging and Drug Delivery. Angew. Chem. Int. Ed. 54, 2431 (2015).

6.   F. Y. Wang, Y. Zhu, L. Zhou, L. Pan, Z. F. Cui, Q. Fei, S. Luo, D. Pan, Q. Huang, R. Wang, C. C. Zhao, H. Tian and C. H. Fan, Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian Cancer-Specific γ-Glutamyltranspeptidase. Angew. Chem. Int. Ed. 54, 7349 (2015).

7.   K. Li, K. Wang, W. Qin, S. Deng, D. Li, J. Y. Shi, Q. Huang and C. H. Fan, DNA-Directed Assembly of Gold Nanohalo for Quantitative Plasmonic Imaging of Single-Particle Catalysis. J. Am. Chem. Soc. 137, 4292 (2015).

8.   B. Dai, D. Li, W. Xi, F. Luo, X. Zhang, M. Zou, M. Cao, J. Hu, W. Wang, G. Wei, Y. Zhang and C. Liu, Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier. Proc. Natl. Acad. Sci. USA 112, 2996 (2015).

9.   J. S. Kahn, A. Trifonov, A. Cecconello, W. Guo, C. Fan and I. Willner, Integration of Switchable DNA-Based Hydrogels with Surfaces by the Hybridization Chain Reaction. Nano Lett. 15, 7773 (2105).

10. G. B. Yao, H. Pei, J. Li, Y. Zhao, D. Zhu, Y. N. Zhang, Y. F. Lin, Q. Huang and C. H. Fan, Clicking DNA to gold nanoparticles: poly-adenine-mediated formation of monovalent DNA-gold nanoparticle conjugates with nearly quantitative yield. NPG Asia Mater. 7,  e159 (2015).

11. J. Chao, Y. Lin, H. Liu, L. Wang and C. Fan, DNA-based plasmonic nanostructures. Mater. Today 18, 326 (2015).

12. C. Wang, M. Ye, L. Cheng, R. Li, W. Zhu, Z. Shi, C. Fan, J. He, J. Liu and Z. Liu, Simultaneous isolation and detection of circulating tumor cells with a microfluidic silicon-nanowire-array integrated with magnetic upconversion nanoprobes. Biomaterials 54, 55 (2015).


1.   N. Chen, J. Li, H. Y. Song, J. Chao, Q. Huang and C. H. Fan, Physical and Biochemical Insights on DNA Structures in Artificial and Living Systems. Acc. Chem. Res. 47, 1720 (2014).

2.   H. Pei, X. L. Zuo, D. Zhu, Q. Huang and C. H. Fan, Functional DNA Nanostructures for Theranostic Applications. Acc. Chem. Res. 47, 550 (2014).

3.   F. Peng, Y. Y. Su, Y. L. Zhong, C. H. Fan, S. T. Lee and Y. He, Silicon Nanomaterials Platform for Bioimaging, Biosensing, and Cancer Therapy. Acc. Chem. Res. 47, 612 (2014).

4.   J. Shen, Y. Li, H. Gu, F. Xia, X. Zuo, Recent Development of Sandwich Assay Based on the Nanobiotechnologies for Proteins, Nucleic Acids, Small Molecules, and Ions. Chem. Rev. 114, 7631 (2014)

5.   H. Xu, Q. Li, L. H. Wang, Y. He, J. Y. Shi, B. Tang and C. H. Fan, Nanoscale optical probes for cellular imaging. Chem. Soc. Rev. 43, 2650 (2014).

6.   J. J. Xu, W. W. Zhao, S. P. Song, C. H. Fan and H. Y. Chen, Functional nanoprobes for ultrasensitive detection of biomolecules: an update. Chem. Soc. Rev. 43, 1601 (2014).

7.   F. Yang, X. L. Zuo, Z. H. Li, W. P. Deng, J. Y. Shi, G. J. Zhang, Q. Huang, S. P. Song and C. H. Fan, A Bubble-Mediated Intelligent Microscale Electrochemical Device for Single-Step Quantitative Bioassays. Adv. Mater. 26, 4671 (2014).

8.   C. H. Fan, J. Hu and Z. Zhao, Synchrotron Light for Materials Science (Editorial for the Special Issue). Adv. Mater. 26, 7685 (2014).

9.   Y. Zhu, T. Earnest, Q. Huang, X. Cai, Z. Wang, Z. Wu and C. Fan, Synchrotron-based X-ray-sensitive nanoprobes for cellular imaging. Adv. Mater. 26, 7889 (2014).

10. L. Yang, D. M. Czajkowsky, J. Sun, J. Hu and Z. Shao, Anomalous Surface Fatigue in a Nano-Layered Material. Adv. Mater. 26, 6478 (2014)

11.   L. Liang, J. Li, Q. Li, Q. Huang, J. Y. Shi, H. Yan and C. H. Fan, Single-Particle Tracking and Modulation of Cell Entry Pathways of a Tetrahedral DNA Nanostructure in Live Cells. Angew. Chem. Int. Ed. 53, 7745 (2014).

12.  J. L. Shen, L. F. Xu, C. P. Wang, H. Pei, R. Z. Tai, S. P. Song, Q. Huang, C. H. Fan and G. Chen, Dynamic and Quantitative Control of the DNA-Mediated Growth of Gold Plasmonic Nanostructures. Angew. Chem. Int. Ed. 53, 8338 (2014).

13. A. Amodio, B. Zhao, A. Porchetta, A. Idili, M. Castronovo, C. H. Fan and F. Ricci, Rational Design of pH-Controlled DNA Strand Displacement. J. Am. Chem. Soc. 136, 16469 (2014).

14. R. X. Duan, X. L. Zuo, S. T. Wang, X. Y. Quan, D. L. Chen, Z. F. Chen, L. Jiang, C. H. Fan and F. Xia, Quadratic isothermal amplification for the detection of microRNA. Nat. Protoc. 9, 597 (2014).

15. B. Zhao, J. L. Shen, S. X. Chen, D. F. Wang, F. Li, S. Mathur, S. P. Song and C. H. Fan, Gold nanostructures encoded by non-fluorescent small molecules in polyA-mediated nanogaps as universal SERS nanotags for recognizing various bioactive molecules. Chem Sci 5, 4460 (2014).

16. L. Yuan, M. Giovanni, J. P. Xie, C. H. Fan and D. T. Leong, Ultrasensitive IgG quantification using DNA nano-pyramids. NPG Asia Mater. 6,  (2014).

17. N. Chen, M. Wei, Y. H. Sun, F. Li, H. Pei, X. M. Li, S. Su, Y. He, L. H. Wang, J. Y. Shi, C. H. Fan and Q. Huang, Self-Assembly of Poly-Adenine-Tailed CpG Oligonucleotide-Gold Nanoparticle Nanoconjugates with Immunostimulatory Activity. Small 10, 368 (2014).

18. N. Chen, H. Wang, Q. Huang, J. Li, J. Yan, D. N. He, C. H. Fan and H. Y. Song, Long-Term Effects of Nanoparticles on Nutrition and Metabolism. Small 10, 3603 (2014).

19. N. Lu, A. R. Gao, P. F. Dai, S. P. Song, C. H. Fan, Y. L. Wang and T. Li, CMOS-Compatible Silicon Nanowire Field-Effect Transistors for Ultrasensitive and Label-Free MicroRNAs Sensing. Small 10, 2022 (2014).

20. X. M. Li, N. Chen, Y. Y. Su, Y. He, M. Yin, M. Wei, L. H. Wang, W. Huang, C. H. Fan and Q. Huang, Autophagy-Sensitized Cytotoxicity of Quantum Dots in PC12 Cells. Adv. Healthc. Mater. 3, 354 (2014).


1.   Y. S. Tu, M. Lv, P. Xiu, T. Huynh, M. Zhang, M. Castelli, Z. R. Liu, Q. Huang, C. Fan, H. P. Fang and R. H. Zhou, Destructive extraction of phospholipids from Escherichia coli membranes by graphene nanosheets. Nature Nanotechnol. 8, 594 (2013).

2.   Dai, B., Kang, S. G., Huynh, T., Lei, H., Castelli, M., Hu, J., ZhangY. and Zhou, R. (2013) Salts Drive Controllable Multi-Layered Upright Assembly of Amyloid-like Peptides at Mica/Water Interface, Proc. Natl. Acad. Sci., USA, 110, 8543-8548.

3.   Y. M. Fu, D. D. Zeng, J. Chao, Y. Q. Jin, Z. Zhang, H. J. Liu, D. Li, H. W. Ma, Q. Huang, K. V. Gothelf and C. Fan, Single-Step Rapid Assembly of DNA Origami Nanostructures for Addressable Nanoscale Bioreactors. J. Am. Chem. Soc. 135, 696 (2013).

4.   N. Wu, D. M. Czajkowsky, J. J. Zhang, J. X. Qu, M. Ye, D. D. Zeng, X. F. Zhou, J. Hu, Z. F. Shao, B. Li and C. Fan, Molecular Threading and Tunable Molecular Recognition on DNA Origami Nanostructures. J. Am. Chem. Soc. 135, 12172 (2013).

5.   Y. Z. Ma, H. N. Zheng, C. E. Wang, Q. Yan, J. Chao, C. Fan and S. J. Xiao, RCA Strands as Scaffolds To Create Nanoscale Shapes by a Few Staple Strands. J. Am. Chem. Soc. 135, 2959 (2013).

6.   R. X. Duan, X. L. Zuo, S. T. Wang, X. Y. Quan, D. L. Chen, Z. F. Chen, L. Jiang, C. Fan and F. Xia, Lab in a Tube: Ultrasensitive Detection of MicroRNAs at the Single-Cell Level and in Breast Cancer Patients Using Quadratic Isothermal Amplification. J. Am. Chem. Soc. 135, 4604 (2013).

7.   C. F. Zhu, Z. Y. Zeng, H. Li, F. Li, C. Fan and H. Zhang, Single-Layer MoS2-Based Nanoprobes for Homogeneous Detection of Biomolecules. J. Am. Chem. Soc. 135, 5998 (2013).

8.   K. Li, W. W. Qin, F. Li, X. C. Zhao, B. W. Jiang, K. Wang, S. H. Deng, C. Fan and D. Li, Nanoplasmonic Imaging of Latent Fingerprints and Identification of Cocaine. Angew. Chem. Int. Ed. 52, 11542 (2013).

9.   J. Li, C. Fan, H. Pei, J. Y. Shi and Q. Huang, Smart Drug Delivery Nanocarriers with Self-Assembled DNA Nanostructures. Adv. Mater. 25, 4386 (2013).

10.   M. H. Lin, H. Pei, F. Yang, C. Fan and X. L. Zuo, Applications of Gold Nanoparticles in the Detection and Identification of Infectious Diseases and Biothreats. Adv. Mater. 25, 3490 (2013).

11. F. Li, H. Pei, L. H. Wang, J. X. Lu, J. M. Gao, B. W. Jiang, X. C. Zhao and C. Fan, Nanomaterial-Based Fluorescent DNA Analysis: A Comparative Study of the Quenching Effects of Graphene Oxide, Carbon Nanotubes, and Gold Nanoparticles. Adv. Funct. Mater. 23, 4140 (2013).

12. J. M. Zhao, B. Deng, M. Lv, J. Y. Li, Y. J. Zhang, H. Q. Jiang, C. Peng, J. Li, J. Y. Shi, Q. Huang and C. Fan, Graphene Oxide-Based Antibacterial Cotton Fabrics. Adv. Healthc. Mater. 2, 1259 (2013).

13. Y. M. Lu, Y. Y. Su, Y. F. Zhou, J. Wang, F. Peng, Y. L. Zhong, Q. Huang, C. Fan and Y. He, In vivo behavior of near infrared-emitting quantum dots. Biomaterials 34, 4302 (2013).

14. X. F. Yang, J. Li, H. Pei, D. Li, Y. Zhao, J. M. Gao, J. X. Lu, J. Y. Shi, C. Fan and Q. Huang, Pattern Recognition Analysis of Proteins Using DNA-Decorated Catalytic Gold Nanoparticles. Small 9, 2844 (2013).

15. X. P. Wei, S. Su, Y. Y. Guo, X. X. Jiang, Y. L. Zhong, Y. Y. Su, C. Fan, S. T. Lee and Y. He, A Molecular Beacon-Based Signal-Off Surface-Enhanced Raman Scattering Strategy for Highly Sensitive, Reproducible, and Multiplexed DNA Detection. Small 9, 2493 (2013).

16. X. Y. Ouyang, J. Li, H. J. Liu, B. Zhao, J. Yan, Y. Z. Ma, S. J. Xiao, S. P. Song, Q. Huang, J. Chao and C. Fan, Rolling Circle Amplification-Based DNA Origami Nanostructrures for Intracellular Delivery of Immunostimulatory Drugs. Small 9, 3082 (2013).

17. B. Zhao, J. Yan, D. F. Wang, Z. L. Ge, S. J. He, D. N. He, S. P. Song and C. Fan, Carbon Nanotubes Multifunctionalized by Rolling Circle Amplification and Their Application for Highly Sensitive Detection of Cancer Markers. Small 9, 2595 (2013).

18. H. Pei, X. L. Zuo, D. Pan, J. Y. Shi, Q. Huang and C. Fan, Scaffolded biosensors with designed DNA nanostructures. NPG Asia Mater. 5, e51  (2013).

19. B. Li, J. Z. Yang, Q. Huang, Y. Zhang, C. Peng, Y. J. Zhang, Y. He, J. Y. Shi, W. X. Li, J. Hu and C. Fan, Biodistribution and pulmonary toxicity of intratracheally instilled graphene oxide in mice. NPG Asia Mater. 5,  e44(2013).

20. Q. S. Chen, H. J. Liu, W. Lee, Y. Z. Sun, D. Zhu, H. Pei, C. Fan and X. D. Fan, Self-assembled DNA tetrahedral optofluidic lasers with precise and tunable gain control. Lab Chip 13, 3351 (2013).


1.   Pei, H., Liang, L., Yao, G., Li, J., Huang, Q. and Fan, C. (2012) Reconfigurable Three-Dimensional DNA Nanostructures for the Construction of Intracellular Logic Sensors. Angew. Chem. Int. Ed., 51, 9020-9024.

2.   Wei, M., Chen, H., Li, J., Yin, M., Liang, L., He, Y., Song, H., Fan, C. and Huang, Q. (2012) Polyvalent immunostimulatory nanoagents with self-assembled CpG oligonucleotide-conjugated gold nanoparticles. Angew. Chem. Int. Ed., 51, 1202-1206.

3.   Gao, A., Lu, N., Wang, Y., Dai, P., Li, T., Gao, X., Wang, Y. and Fan, C. (2012) Enhanced sensing of Nucleic Acids with Silicon Nanowire Felid Effect Transistor Biosensors. Nano Lett., 12, 5262-5268.

4.   Pei, H., Li, J., Lv, M., Wang, J., Gao, J., Lu, J., Li, Y., Huang, Q., Hu, J. and Fan, C. (2012) A graphene-based sensor array for high-precision and adaptive target identification with ensemble aptamers. J. Am. Chem. Soc., 134, 13843-13849

5.   Pei, H., Li, F., Wan, Y. Wei, M., Liu, H., Su, Y., Chen, N., Huang, Q. and Fan, C. (2012) Designed diblock oligonucleotide for the synthesis of spatially isolated and highly hybridizable functionalization of DNA-gold nanoparticle nanoconjugates. J. Am. Chem. Soc., 134, 11876-11879.

6.   Lu, N., Pei, H., Ge, Z., Simmons, C., Yan, H. and Fan, C. (2012) Charge transport within a three-dimensional DNA nanostructure framework. J. Am. Chem. Soc., 134, 13148-13151.

7.   Su, S., Wei, X., Zhong, Y., Guo, Y., Su, Y., Huang, Q., Lee, S.-T., Fan, C. and He, Y. (2012) Silicon Nanowire-Based Molecular Beacons for High-Sensitivity and Sequence-Specific DNA Multiplexed Analysis. ACS Nano, 6, 2582-2590.

8.   Chen, N., He, Y., Su, Y., Li, X., Huang, Q., Wang, H., Zhang, X., Tai, R. and Fan, C. (2012) The cytotoxicity of cadmium-based quantum dots. Biomaterials, 33, 1238-11244.

9.   Zhu, Y., Li, W., Zhang, Y., Li, J., Liang, L., Zhang, X., Chen, N., Sun, Y., Chen, W., Tai, R., Fan, C. and Huang, Q. (2012) Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy. Small, 11, 1771-1779.


1.   Chen, P., Pan, D., Fan, C., Chen, J., Huang, K., Wang, D., Zhang, H., Li, Y., Feng, G., Liang, P., He, L. and Shi, Y. (2011) Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nature Nanotechnol., 6, 639-644.

2.   Zheng, X., Liu, Q., Jing, C., Li, Y., Li, D., Luo, W., Wen, Y., He, Y., Huang, Q., Long, Y. and Fan, C. (2011) Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization. Angew. Chem. Int. Ed., 50, 11994-11998.

3 He, Y., Zhong, Y., Su, Y., Lu, Y., Jiang, Z., Peng, F., Xu, T., Su, S., Huang, Q., Fan, C. and Lee, S.-T. (2011) Water-Dispersed Near-Infrared-Emitting Quantum Dots of Ultrasmall Sizes for In Vitro and In Vivo Imaging. Angew. Chem. Int. Ed., 50, 5695-5698.

4  Gao, A., Lu, N., Dai, P., Li, T., Pei, H., Gao, X., Gong, Y., Wang, Y. and Fan, C. (2011) Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids. Nano Lett., 11, 3974-3978.

5.   Wang, L., Pu, K., Li, J., Qi, X., Li, H., Zhang, H., Fan, C. and Liu, B. (2011) A Graphene/Conjugated Oligomer Hybrid Probe for Light-up Sensing of Lectin and Escherichia coli. Adv. Mater., 23, 4386-4391.

6.   He, Y., Su, S., Xu, T., Zhong, Y., Zapien, A., Li, J., Fan, C. and Lee, S.-T. (2011) Silicon Nanowires-Based Highly-Efficient SERS-Active Platform for Ultrasensitive DNA Detection. Nano Today, 6, 122-130.

7.   Peng, C., Jiang, B., Liu, Q., Guo, Z., Xu, Z., Huang, Q., Xu, H., Tai, R. and Fan, C. (2011) Graphene-templated formation of two-dimensional lepidocrocite nanostructures for high-efficiency catalytic degradation of phenols. Energy Environ. Sci., 4, 2035-2040.

8.   Li, J., Pei, H., Zhu, B., Liang, L., Wei, M., He, Y., Chen, N., Li, D., Huang, Q. and Fan, C. (2011) Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides. ACS Nano, 5, 8783-8789.

9.   Hu, W., Peng, C., Lv, M., Li, X., Zhang, Y., Chen, N., Fan, C. and Huang, Q. (2011) Protein Corona-Mediated Mitigation on Cytotoxicity of Graphene Oxide. ACS Nano, 5, 5, 3693-3670.

10.   Su, Y., Peng, F., Jiang, Z., Zhong, Y., Lu, Y., Jiang, X., Huang, Q., Fan, C., Lee, S.-T. and He, Y. (2011) In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots. Biomaterials, 32, 5855-5862.

11.   He, Y., Lu, H., Su, Y., Sai, L., Hu, M., Fan, C. and Wang, L. (2011) Ultra-photostable, non-cytotoxic, and highly fluorescent quantum nanospheres for long-term, high-specificity cell imaging. Biomaterials, 32, 2133-2140.


1.   Li, D., Song, S. and Fan, C. (2010) Target-responsive structures for nucleic acid sensors. Acc. Chem. Res., 43, 631-641.

2.   Song, S., Qin, Y., He, Y., Huang, Q., Fan, C. and Chen, H. (2010) Functional nanoprobes for ultrasensitive detection of biomolecules. Chem. Soc. Rev., 39, 4234-4243.

3.   He, Y., Fan, C. and Lee, S.-T. (2010) Silicon nanostructures for bioapplications. Nano Today, 5, 282-295.

4.   Luo, C., Zheng, H., Wang, L., Fang, H., Hu, J., Fan, C., Cao, Y. and Wang, J. (2010) Direct 3D Imaging of the Buried Interfaces between Water and Superhydrophobic Surfaces. Angew. Chem. Int. Ed., 49, 9145-9148 (Featured in Nature China).

5.   Yang, Y., Liu, G., Liu, H., Li, D., Fan, C. and Liu, D. (2010) An electrochemically actuated reversible DNA switch. Nano Lett., 10, 1393-1397 (Featured in Nature China).

6.   Liu, G., Sun, C., Li, D., Song, S., Mao, B., Fan, C. and Tian, Z. (2010) Gating of redox currents at gold nanoelectrodes via DNA hybridization. Adv. Mater., 22, 2148-2150.

7.   Zhang, Z., Wang, Y., Fan, C., Li, C., Li, Y., Qian, L., Fu, Y., Shi, Y., Hu, J. and He, L. (2010) Asymmetric DNA origami for spatially addressable and index-free solution-phase DNA chips. Adv. Mater., 22, 2672-2675.

8.   Lv, M., Su, S., He, Y., Huang, Q., Hu, W., Li, D., Fan, C. and Lee, S.-T. (2010) Long-term antimicrobial effect of silicon nanowires decorated with silver nanoparticles. Adv. Mater., 22, 5463-5467.

9.   Pei, H., Lu, N., Wen, Y., Song, S., Liu, Y., Yan, H. and Fan, C. (2010) A DNA Nanostructure-based Biomolecular Probe Carrier Platform for Electrochemical Biosensing. Adv. Mater., 22, 4754-4758.

10. Deng, B., Cai, R., Yu, Y., Jiang, H., Wang, C., Li, J., Li, L., Yu, M., Li, J., Xie, L., Huang, Q. and Fan, C. (2010) Laundering durability of superhydrophobic cotton fabric. Adv. Mater., 22, 5473-5477.

11.  Hu, W., Peng, C., Luo, W., Lv, M., Li, X., Li, D., Huang, Q. and Fan, C. (2010) Graphene-based antibacterial paper. ACS Nano, 4, 4317-4323.

12. Hu, M., Yan, J., He, Y., Lu, H., Weng, L., Song, S., Fan, C. and Wang, L. (2010) Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot based microfluidic protein chip. ACS Nano, 4, 488-494.

13. Zhang, F., Zhang, F., Su, H., Li, H., Zhang, Y., Hu, J. (2010) Mechanical Manipulation Assisted Self-Assembly To Achieve Defect Repair and Guided Epitaxial Growth of Individual Peptide Nanofilaments. ACS Nano, 4, 5791-5796.

14. Luo, W., Zhu, C., Su, S., Li, D., He, Y., Huang, Q. and Fan, C. (2010) Self-catalyzed, Self-limiting Growth of Glucose Oxidase-Mimicking Gold Nanoparticles. ACS Nano, 4, 7451-7458.

15. Zhou, Y., Huang, Q., Gao, J., Lu, J., Shen, X. and Fan, C. (2010) A dumbbell probe-mediated rolling circle amplification strategy for highly sensitive microRNA detection. Nucleic Acids Res., 38, e156.

16. Su, Y., Hu, M., Fan, C., He, Y., Li, Q., Li, W., Wang, L., Shen, P. and Huang, Q. (2010) The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties. Biomaterials, 31, 4829-4834.

17. Li, J., Zhu, Y., Li, W., Zhang, X., Peng, Y., Huang, Q. (2010) Nanodiamonds as intracellular transporters of chemotherapeutic drug. Biomaterials, 31, 8410-8418

18. He, Y., Lu, H., Su, Y., Sai, L., Hu, M., Fan, C. and Wang, L. (2010) Ultra-photostable, Non-cytotoxic, and Highly Fluorescent Quantum Nanospheres for Long-Term, High-Specificity Cell Imaging. Biomaterials, 32, 2133-2140.

19. He, S., Song, B., Li, D., Zhu, C., Qi, W., Wen, Y., Wang, L., Song, S., Fang, H. and Fan, C. (2010) A graphene nanoprobe for rapid, sensitive and multicolor fluorescent DNA analysis. Adv. Funct. Mater., 20, 453-459.

20. Zhang, J., Wang, L., H. Zhang, Boey, F., Song, S. and Fan, C. (2010) Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution. Small, 6, 201-204.

21. Peng, C., Hu, W., Zhou, Y., Fan, C. and Huang, Q. (2010) Intracellular imaging with a graphene-based fluorescent probe. Small, 6, 1686-1692.

22. Zhang, Z., Zeng, D., Ma, H., Feng, G., Hu, J., He, L., Li, C. and Fan, C. (2010) A DNA-Origami Chip Platform for Label-Free SNP Genotyping Using Toehold-Mediated Strand Displacement. Small, 6, 1854-1858 (Frontispiece paper).

23. Yan, J., Song, S., Li, B., Huang, Q., Zhang, Q., Zhang, H. and Fan, C. (2010) An on-nanoparticle rolling circle amplification platform for ultrasensitive protein detection in biological fluids. Small, 6, 2520-2525.


1.    Song, S., Liang, Z., Zhang, J., Wang, L., Li, G. and Fan, C. (2009) Gold-Nanoparticle-Based Multicolor Nanobeacons for Sequence-Specific DNA Analysis. Angew. Chem. Int. Ed., 48, 8670-8674. (Frontpiece paper & Featured in Nature China)

2.    He, Y., Kang, Z., Li, Q., Tsang, C.H.A., Fan, C. and Lee, S.-T. (2009) Ultrastable, Highly Fluorescent, and Water-Dispersed Silicon-Based Nanospheres as Cellular Probes. Angew. Chem. Int. Ed., 48, 128-132.

3.    He, Y., Su, Y., Yang, X., Kang, Z., Xu, T., Zhang, R., Fan, C. and Lee, S.-T. (2009) Photo and pH Stable, Highly-Luminescent Silicon Nanospheres and Their Bioconjugates for Immunofluorescent Cell Imaging. J. Am. Chem. Soc., 131, 4434-4438.

5.   Wang, C., Lu, H., Wang, Z., Xiu, P., Zhou, B., Zuo, G., Wan, R., Hu, J. and Fang, H. (2009) Stable Liquid Water Droplet on a Water Monolayer Formed at Room Temperature on Ionic Model Substrates. Phys. Rev. Lett., 103, 137801.

6.   Mi, L., Wen, Y., Pan, D., Wang, Y., Fan, C. and Hu, J. (2009) Modulation of DNA Polymerases with Gold Nanoparticles and their Applications in Hot-Start PCR. Small, 5, 2597-2600.

7.   Su, Y., He, Y., Lu, H., Sai, L., Li, Q., Li, W., Wang, L., Shen, P., Huang, Q. and Fan, C. (2009) The cytotoxicity of cadmium based, aqueous phase-synthesized, quantum dots and its modulation by surface coating. Biomaterials, 30, 19-25.


1.    Luo, C., Zuo, X., Wang, L., Wang, E., Song, S., Wang, J., Wang, J., Fan, C. and Cao, Y. (2008) Flexible Carbon Nanotube-Polymer Composite Films with High Conductivity and Superhydrophobicity Made by Solution Process. Nano Lett., 8, 4454-4458.

2.    He, Y., Lu, H., Sai, L., Su, Y., Hu, M., Fan, C., Huang, W. and Wang, L. (2008) Microwave synthesis of water-dispersed CdTe/CdS/ZnS core-shell-shell quantum dots with excellent photostability and biocompatibility. Adv. Mater., 20, 3416-3421.

3.    Liu, G., Wan, Y., Gau, V., Zhang, J., Wang, L., Song, S. and Fan, C. (2008) An enzyme-based E-DNA sensor for sequence-specific detection of femtomolar DNA targets. J. Am. Chem. Soc., 130, 6820-6825.

4.    Li, J., Song, S., Liu, X., wang, L., Pan, D., Huang, Q., Zhao, Y. and Fan, C. (2008) Enzyme-based multi-component optical nanoprobes for sequence-specific detection of DNA hybridization. Adv. Mater., 20, 479-500.

5.    Zhang, J., Wang, L., Pan, D., Song, S., Boyer, F.Y., Zhang, H. and Fan, C. (2008) Visual Cocaine Detection with Gold Nanoparticles and Rationally Engineered Aptamer Structures. Small, 4, 1196-1200.


1.   Gong, X., Li, J.,  Lu, H., Wan, R., Li, J., Hu, J., Fang, H. (2007) A charge driven molecular water pump, Nature Nanotechnology, 2, 709-712.

2.   Li, J., Gong, X., Lu, H., Li, D., Fang, H., and Zhou, R. (2007) Electrostatic gating of a nanometer water channel, Proc. Natl. Acad. Sci. USA, 104, 3687-3692

3   Zhang, J., Song, S., Wang, L., Pan, D. and Fan, C. (2007) A gold nanoparticle-based chronocoulometric DNA sensor for amplified detection of DNA. Nature Protocols, 2, 2888-2895.

4   Wang, J., Wang, L., Liu, X., Liang, Z., Song, S., Li, W., Li, G. and Fan, C. (2007) A gold nanoparticle-based aptamer target binding readout for ATP assay. Adv. Mater., 19, 3943-3946.

5.    Zuo, X., Song, S., Zhang, J., Pan, D., Wang, L. and Fan, C. (2007) A target-responsive electrochemical aptamer switch (TREAS) for reagentless detection of nanomolar ATP. J. Am. Chem. Soc., 129, 1042-1043.

6  Li, B., Zhang, Y., Yan, Y., Lu, J., Ye, M., Li, M., Hu, J. (2007) Positioning scission of single DNA molecules with nonspecific endonuclease based on nanomanipulation, J. Am. Chem. Soc., 129, 6668-6669.

7.   Liu, X., Tang, Y., Wang, L., Zhang, J., Song, S., Fan, C. and Wang, S. (2007) Optical detection of mercury (II) in aqueous solutions using conjugated polymers and label-free oligonucleotides. Adv. Mater., 19, 1471-1474.


1.    Chen, X., Wang, Y., Liu, Q., Zhang, Z., Fan, C. and He, L. (2006) Construction of molecular logic gates with a DNA-cleaving deoxyribozyme. Angew. Chem. Int. Ed., 45, 1759-1762.

2.    Zhang, F., Du, H., Zhang, Z., Ji, L., Li, H., Tang, L., Wang, H., Fan, C., Xu, H., Zhang, Y. et al. (2006) Epitaxial Growth of Peptide Nanofilaments on Inorganic Surfaces: Effects of Interfacial Hydrophobicity/Hydrophilicity. Angew. Chem. Int. Ed., 45, 3611-3613.

3.   Zhang, J., Song, S., Zhang, L., Wang, L., Wu, H., Pan, D. and Fan, C. (2006) Sequence-specific detection of femtomolar DNA via a chronocouloumetric DNA sensor (CDS): Effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes. J. Am. Chem. Soc., 128, 8575-8580.

4.  Coexistence of liquid and solid phases of bmim-PF6 ionic liquid on mica surfaces at room temperature, Liu, Y., Zhang, Y.*, Wu, G.*, Hu, J. J. Am. Chem. Soc., 2006, 128, 7456-7457.

5.  Ouyang, Z., Tan, L., Liu, M., Judge, O. S., Zhang, X., Li, H., Hu, J., Patten, T. E. and Liu, G. (2006) A Simple Miniaturization Protocol to Produce Multicomponent Micro-and Nanostructures. Small, 2, 884-887.

Before 2006

1.      Wan, R., Li, J., Lu, H., Fang, H. (2005) Controllable water channel gating of nanometer dimensions, J. Am. Chem. Soc., 127, 7166-7170.

2.      Li, H., Huang, J., Lv, J., An, H., Zhang, X., Zhang, Z., Fan, C. and Hu, J. (2005) Nanoparticle PCR: Nanogold-assisted PCR with enhanced specificity. Angew. Chem. Int. Ed., 44, 5100.

3.      Lu, J., Li, H., An, H., Wang, G., Wang, Y., Li, M., Zhang, Y.,  Hu, J. (2004) Positioning isolation and biochemical analysis of single DNA molecules based on nanomanipulation and single-molecule PCR, J. Am. Chen. Soc., 126, 11136-11137.

4.      Fan, C., Plaxco, K.W. and Heeger, A.J. (2005) Biosensors based on binding-modulated donor-acceptor distances. Trends in Biotechnology, 23, 186-192.

5.   Hu, J. Zhang, Y., Gao, H., Li, M. and hartmann, U. (2002) Artificial DNA patterns by mechanical nanomanipulation, Nano Lett., 2, 55-57.

6.   Xu, H., Wu, H., Huang, F., Song, S., Li, W., Cao, Y. and Fan, C. (2005) Magnetically assisted DNA assays: High selectivity using conjugated polymers for amplified fluorescent transduction. Nucleic Acids Res., 33, e83.

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