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                                          Dr. Di Li, Professor

                                                          Research area: nanobiosensors

                                                                                 DNA machine

                                                           Tel: (021)39194663

                                                           E-mail: lidi@sinap.ac.cn

  

Dr Li completed his BSc studies at the Dalian University of technology in 2000. He completed his Ph D studies in chemistry at the Changchun Institute of Applied Chemistry, Chinese Academy of Sciences in 2005. From 2005 to 2008, he worked as a postdoctoral fellow with Prof. Itamar Willner at the Hebrew University of Jerusalem on the development of novel DNA nanomachine. He then joined the SINAP at 2008. His research interests include the development of DNA sensors, aptasensors. He is also involved in the design of aptamers and DNAzymes based DNA machine for amplified sensing.

Recent publications

1. Li, D., Wieckowska, A., and Willner, I. (2008) Optical Analysis of Hg2+ ions by oligonucleotide-Au nanoparticles hybrids and DNA-based machines, Angew. Chem. Int. Ed., 47, 3927-3931.

2. Li, D., Shlyahovsky, B., Elbaz, J., and Willner, I. (2007) Amplified analysis of low molecular weight substrates or proteins by the self-assembly of DNAzyme-aptamer conjugates, J. Am. Chem. Soc., 129, 5804-5805.

3. Shlyahovsky, B., Li, D., Weizmann, Y., Nowarski,, R., Kotler, M., and Willner, I. (2007) Spotlighting of cocaine by an autonomous aptamer-based machine, J. Am. Chem. Soc., 129, 3814-3815

4. Zhu, C., Wen, Y., Li, D. *, Wang, L., Song, S., Fan, C.* and Willner, I. (2009) Inhibition of the In Vitro Replication of DNA by an Aptamer–Protein Complex in an Autonomous DNA Machine. Chem. Eur. J., 15, 11898-11903.

5. Zhu, Z., Su, Y., Li, J., Li, D.*, Zhang, J., Song, S., Zhao, Y., Li, G.* and Fan, C. (2009) Highly Sensitive Electrochemical Sensor for Mercury(II) Ions by Using a Mercury-Specific Oligonucleotide Probe and Gold Nanoparticle-Based Amplification. Anal. Chem., 81, 7660-7666.

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